The role of ceramides in skin

Ceramides can be found in the epidermis and make up approximately 50% of the skin's lipid composition of the outermost layer of the skin.⁵

Ceramides are a critical component of the lipid composition within the epidermis, acting as a bonding agent that holds the skin cells together. These help the skin maintain its protective layer that both retains moisture and acts as a barrier against bacteria, environmental pollutants and allergens.

Many factors can cause a change in the barrier lipid composition, leading to skin disorders. While the link is unclear, most skin disorders with a diminished barrier function show a decrease in total ceramide content, with some differences in ceramide pattern.⁶

It is possible to chemically recreate ceramides that occur naturally in the skin. These ceramides can be added to emollients, are easy to absorb and are used to improve compromised skin conditions.⁷