Recommending Maloff Protect
Recommending Maloff Protect
Maloff Protect (atovaquone 250mg/proguanil hydrochloride 100mg) is a medicine recently reclassified from POM to P. It can be used as chemoprophylaxis for malaria. It is particularly effective against drug-sensitive and drug-resistant P. falciparum so is especially recommended where the pathogen may be resistant to other anti-malarials.
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Who is it for?close
Maloff Protect is suitable for people over 18 years that weigh over 40kg for chemoprophylaxis of
P. falciparum malaria -
What is the dosage?close
One tablet daily with food or a milky drink (to ensure maximum absorption) at the same time each day. Customers should commence the course 1-2 days prior to entering a malaria-endemic area, continue during the period of the stay and continue for 7 days after leaving the area
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Contraindicationsclose
Hypersensitivity to active ingredients, severe renal impairment, pregnancy/breastfeeding,
kidney disease, history of depression, epilepsy, tuberculosis. -
Potential side effectsclose
The most commonly reported side effects include headache, nausea and vomiting, abdominal pain and diarrhoea
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Interactions with other medicationclose
Include: efavirenz or boosted protease inhibitors, etoposide, metoclopramide, rifampicin or rifabutin, tetracycline, warfarin and other coumarin-based anticoagulants
Further information
Maloff Protect Risk Management Materials are available to download at the end of this module.
Pharmacy checklist
When recommending Maloff Protect there is a useful Pharmacy Checklist which covers the range of steps involved in recommending Maloff Protect, from checking the chemoprophylaxis required, through calculating the dose and issuing reminder cards and reminding customers to have a full travel consultation (see Resources page).
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