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Proton pump inhibitors (PPIs) are associated with an increased risk of myocardial infarction (MI) and cardiovascular mortality, a new analysis of 2.9 million people has suggested. Gastro-oesophageal reflux disease (GORD) patients who had taken PPIs were 16 per cent more likely to have a MI than GORD patients who did not use PPIs. In addition, PPIs were associated with a doubling in cardiovascular mortality after allowing for other cardiovascular co-morbidities.

Previous studies associated PPIs with adverse outcomes in people taking clopidogrel after acute coronary syndrome. In this new study, the link between PPIs and MI was independent of clopidogrel or age-related risks. (PLOS One DOI: 10.1371/ journal.pone.0124653)